Caloric restriction and body weight independently affect longevity in Wistar rats
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چکیده
منابع مشابه
Caloric restriction stabilizes body weight and accelerates behavioral recovery in aged rats after focal ischemia
Obesity and hyperinsulinemia are risk factors for stroke. We tested the hypothesis that caloric restriction, which reduces the incidence of age-related obesity and metabolic syndrome, may represent an efficient and cost-effective strategy for preventing stroke and its devastating consequences. To this end, we placed aged, obese Sprague-Dawley aged rats on a calorie-restricted diet for 8 weeks p...
متن کامل[Effect of caloric restriction on longevity].
Calorie restriction (CR) is the most evaluated nutritional intervention to increase lifespan in a variety of animal species, including human beings. CR has also been shown to delay the onset or reduce the incidence of many age-related diseases. The mechanism that could explain the effect of calorie intake on aging is related to the reduction of body fat and insulin signaling as well as reactive...
متن کاملCaloric restriction improves basal redox parameters in hippocampus and cerebral cortex of Wistar rats
Caloric restriction (CR) has been shown to either decrease or prevent the progression of several age-related pathologies. In previous work, we demonstrated that CR modulates astrocyte functions, suggesting that CR may exert neuroglial modulation. Here, we investigated the effects of CR on hippocampal (Hc) and cortical (Cx) oxidative stress parameters of male Wistar rats. Our results showed that...
متن کاملToward a unified theory of caloric restriction and longevity regulation.
The diet known as calorie restriction (CR) is the most reproducible way to extend the lifespan of mammals. Many of the early hypotheses to explain this effect were based on it being a passive alteration in metabolism. Yet, recent data from yeast, worms, flies, and mammals support the idea that CR is not simply a passive effect but an active, highly conserved stress response that evolved early i...
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Background The use of non-caloric sweeteners can interfere in the regulation of appetite, promoting greater food intake and weight gain. In previous data, our results showed that animals who consumed yogurt with saccharin and aspartame had a increase in weight compared to the group using sucrose. However, as the total calorie intake was similar between the groups, we speculated that weight gain...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2004
ISSN: 0307-0565,1476-5497
DOI: 10.1038/sj.ijo.0802518